What is a Single-Domain Antibody? Single-Domain antibodies (sdAbs), also known as Nanobodies, are small antigen-binding fragments (~15 kDa) that are derived from heavy chain only antibodies present in camelids (VHH, from camelids), and cartiaginous fishes (VNAR, from sharks). Online Inquiry Advantages of sdAbs Small size, molecular weight of only ~15 KDa, than conventional antibody ~150 KdaEnhanced tissue penetration, can cross the blood-brain barrierUnique binding capacity to small cavities or cleftsHigh affinity and specificityHighly stable under extreme temperature and pHHigh solubility, great imaging agents due to rapid clearance in vivoCan be readily selected and produced in bacterial and yeastsCost-effective, virtually unlimited supply at constant high quality without batch-to-tach variations. Our Services We carry out sdAbs development through both Immune and Naïve phage libraries.Customized library construction services under M13 filamentous phage display systemA large number of animals available, established and optimized workflow for camel, alpaca and shark immunizationProfessional animal handling and caringBig capacity: capable of carrying out multiple projects at the same timeFlexible schedule: we can start the project once antigen is readyStrong specificity: we are able to target proteins with 1-10 amino acids differencesSmall and large scale expression of proteins in E.coli and Pichia Pastoris workflow