Common Recombinant subunit vaccine expressed in Pichia pastoris

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Subunit vaccines often suffer from poor immunogenicity and require certain helper molecules known as adjuvants to induce or enhance an appropriate immune response to the antigen. T‐cell activation is crucial in inducing protective immune responses. Antigens mannosylated by P. pastoris have shown to have enhanced antigen presentation and T‐cell activation properties compared with their nonglycosylated counterparts. Therefore, glycoproteins derived from P. pastoris have the potential to function as adjuvants.

Construct nameUsed strainUsed vectorTargeted disease
PIMP‐V1 and PIMP‐V2KM71pPICZαAMalaria
P1‐3CDPichiaPinkpPink‐HCHand–foot–mouth disease
DENV‐3 EKM71pPICZ‐ADengue
CHIKV‐C‐E3‐E2‐6K‐E1GS115pPIC9KChikungunya
Gp350GS115pPICZαAEBV infection
RBD219‐N1X‐33pPICZαASARS
VP2–VP5–FcGS115pPIC9KInfectious bursal
F proteinGS115pPICZαANewcastle
OmpAGS115pPIC9KP. mirabilis infection
BoNT HcX‐33pPICZ‐ABotulism
Tc52GS115pPICZαAChagas
ApaGS115pPIC9KTuberculosis
HBHAGS115pPIC9KTuberculosis
CFP10‐Fcγ2aGS115pPICZαATuberculosis
ESAT6‐CFP10‐Fcγ2aGS115pPICZαATuberculosis
ESAT6‐Fcγ2aGS115pPICZαATuberculosis
CFP10‐HspX‐Fcγ2aGS115pPICZαATuberculosis
ESAT6‐HspX‐Fcγ2aGS115pPICZαATuberculosis
Glycoprotein DGS115pPIC9KHSV‐2 infection
OmpA‐FcGS115pPIC9KBordetellosis

Table: Common Recombinant Subunit Vaccine Expressed In Pichia Pastoris

Ref: Pichia pastoris: A highly successful expression system for optimal synthesis of heterologous proteins

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